A Powerful Natural Antioxidant for Health and Beauty

Alpha Lipoic Acid Helps Chemotherapy Work Better

Antioxidants may help chemotherapy cancer treatment.

Evidence shows that alpha lipoic acid can reduce the side effects of conventional cancer therapy. Alpha lipoic acid may also improve the effectiveness of some chemo drugs. Some examples include: (iv.726)

Table IV.3: Effects of Alpha Lipoic Acid with Chemotherapy
CANCER TYPE ALPHA LIPOIC ACID DOSAGE CHEMOTHERAPY OVERALL ACTIVITY

COLORECTAL CANCER

(Advanced Metastatic)

Clinical Study

Clinical Study

600 mg alpha lipoic acid by i.v. once a week for 3-5 weeks followed by 1800 mg/day until fully recovered (max. 6 months).

Oxaliplatin

Raltitrexed

Severity, intensity, and duration of peripheral neuropathy (nerve damage) caused by chemo in over 50% of patients. (iv.7)

The remaining patients did not respond to alpha lipoic acid treatment, but were not worsened by it either. The only reported adverse side effects possibly due to alpha lipoic acid were moderate stomach pain or nausea in a few patients. (iv.7)

GASTRIC CANCER

(Advanced)

Clinical Study

Clinical Study

600 mg alpha lipoic acid by i.v. once a week for 3-5 weeks followed by 1800 mg/day for up to 6 months.

Docetaxel

Cisplatin

Peripheral neuropathy within 4 weeks (on average) of treatment. (iv.27)

LEUKEMIA

Animal Study

16 mg/kg body weight alpha lipoic acid injection.

Doxorubicin (iv.13)

Survival. (iv.26)

Heart damage(iv.26)

Liver damage and secondary cancers in pregnant females, as well as liver damage in offspring exposed in utero. (iv.28)

PANCREATIC CANCER

(Metastatic)

Case Report

1200 mg/day; 80 year old woman with advanced ductal adenocarcinoma.

Gemcitabine

Hydroxycitrate

Celecoxib

Retinoic acid

Melatonin

Prosure (following surgery)

Survival. (iv.5)

Markers for cancer cell metabolism. (iv.5)

Metastatic tumors in liver. (iv.5)

Quality of life (excellent, with no complaints). (iv.5)

Loss of weight due to cancer. (iv.5)

SARCOMA;

WALKER CARCINOMA

Animal Study

10-40 mg/kg body weight oral alpha lipoic acid.

Cyclophosphamide Negative side effects. (iv.13)

Animal Study

10-40 mg/kg body weight oral alpha lipoic acid.

Vincristine sulfate

Survival. (iv.26)

Negative side effects. (iv.1326)

Drug-induced diabetes(iv.26)

Animal Study

25-100 mg/kg body weight alpha lipoic acid injection.

Cisplatin

Hearing loss(iv.13)

Kidney damage(iv.13)

VARIOUS CANCERS

Animal Studies

Bleomycin (iv.32)

Cyclophosphamide (iv.2631)

Usually irreversible lung damage. (iv.32-33)

Drug-induced diabetes(iv.26)

DNA damage to sperm and testicular cells. (iv.31)

Risk of chemo-induced male infertility and sterility(iv.31)

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